Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.
Transplantation. 2013 Jan 27;95(2):378-82. doi: 10.1097/TP.0b013e318270f370.
Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative.
We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa.
Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection.
These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.
慢性排斥反应是小肠移植存活的一个重大障碍。虽然慢性排斥反应主要涉及黏膜下、浆膜和肠系膜的血管，但有人提出一些黏膜改变与之相关。
我们回顾性地研究了移植小肠的临床特征和黏膜、黏膜下层和浆膜的组织学改变。
隐窝上皮黏蛋白丢失、黏膜下层纤维化和移植时间与慢性排斥反应均有统计学关联。浆膜和肠系膜的中、大血管优先表现出慢性排斥反应的组织学改变。
这些结果进一步定义了慢性血管排斥反应以及黏膜改变与慢性排斥反应之间的关系。
