Takács Gábor, Szalay Cs, Nagy B, Szabó I, Simon D, Berki T, Karádi Z
Institute of Physiology and Neurophysiology Research Group, Hungarian Academy of Sciences Pécs, Hungary.
Acta Physiol Hung. 2012 Dec;99(4):472-8. doi: 10.1556/APhysiol.99.2012.4.11.
The nucleus accumbens (NAcc), an important basal forebrain structure, has a central integratory function in the control of feeding and metabolism. The primary cytokine interleukin-1β (IL-1β) exerts its neuromodulatory effects on the endocrine functions both centrally and peripherally. The present study was designed to elucidate the possible consequences of direct administration of IL-1β into the NAcc on the endocrine regulation of metabolism. Plasma concentrations of insulin and leptin, two key hormones in the homeostatic control were determined 15 minutes after a single bilateral microinjection of IL-1β into the NAcc of adult male Wistar rats, and the effects were compared with those found in vehicle treated control animals. Insulin plasma levels of the cytokine treated animals were significantly higher than those parameters of the control rats. No differences were found in leptin plasma concentrations between the two groups. Our findings show that IL-1β mediated processes in the NAcc have important roles in the central neuroendocrine control.
伏隔核（NAcc）是前脑基部的一个重要结构，在进食和新陈代谢的控制中具有核心整合功能。主要细胞因子白细胞介素-1β（IL-1β）在中枢和外周对内分泌功能发挥神经调节作用。本研究旨在阐明向伏隔核直接注射IL-1β对新陈代谢内分泌调节的可能影响。在成年雄性Wistar大鼠的伏隔核进行单次双侧微量注射IL-1β后15分钟，测定了稳态控制中的两种关键激素胰岛素和瘦素的血浆浓度，并将其效果与接受溶剂处理的对照动物进行比较。细胞因子处理动物的胰岛素血浆水平显著高于对照大鼠的相应参数。两组之间的瘦素血浆浓度未发现差异。我们的研究结果表明，伏隔核中IL-1β介导的过程在中枢神经内分泌控制中具有重要作用。
