Schmid-Schönbein G W, Delano F A, Chu S, Zweifach B W
AMES-Bioengineering, University of California San Diego, La Jolla 92093.
Int J Microcirc Clin Exp. 1990 Feb;9(1):47-66.
Vessel wall structure in feed arteries and their hierarchical ramifications were investigated in a rat skeletal muscle. Emphasis was placed on the transition of wall structure elements from the axillary and thoracodorsal arteries to the feeder arteries and the arcade and transverse arterioles forming the microcirculation of the spinotrapezius muscle. Semi-thin sections, prepared for light microscopy, and ultra-thin sections for electron microscopy were used to compare mature (15-20 week old) normotensive and hypertensive animals. The results demonstrate a gradual transition of the elastica intima and the smooth muscle from the central arteries towards the arterioles, accompanied by an attenuation of the adventitia. The elastica intima in 60-40 microns arcade arterioles is reduced from a continuous sheet in the central arteries to single fibers oriented parallel to the vessel axis. The multiple layers of smooth muscle cells at the level of the feeder arteries are reduced in the majority of arcade arterioles and in transverse arterioles to a single smooth muscle coat. Comparisons of the smooth muscle mass per unit length of vessel at selected sites of normotensive and spontaneously hypertensive rats show evidence for some degree of wall hypertrophy in the axillary artery, but no evidence for wall hypertrophy in arterioles of the microcirculation. There is no evidence of a pressure-mediated structural medial wall hypertrophy along this peripheral vascular pathway.
在大鼠骨骼肌中研究了供血动脉及其分级分支的血管壁结构。重点关注从腋动脉和胸背动脉到供血动脉以及形成斜方肌微循环的弓状动脉和横行小动脉的壁结构成分的转变。制备用于光学显微镜检查的半薄切片和用于电子显微镜检查的超薄切片，以比较成熟（15 - 20周龄）的正常血压和高血压动物。结果表明，弹性内膜和平滑肌从中央动脉向小动脉逐渐过渡，同时外膜变薄。在60 - 40微米的弓状动脉中，弹性内膜从中央动脉的连续薄片减少为与血管轴平行排列的单纤维。供血动脉水平的多层平滑肌细胞在大多数弓状动脉和横行小动脉中减少为单层平滑肌。对正常血压和自发性高血压大鼠选定部位血管单位长度平滑肌质量的比较显示，腋动脉有一定程度的壁肥厚，但微循环小动脉没有壁肥厚的证据。沿这条外周血管通路没有压力介导的结构性中膜壁肥厚的证据。
