Paweł Knapp, Chabowski Adrian, Górski Jan
Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, 24a Skłodowskiej Str., 15-269 Białystok, Poland.
Lipids. 2013 Mar;48(3):245-50. doi: 10.1007/s11745-012-3746-2. Epub 2012 Dec 14.
In the present work we sought to investigate the content of sphingolipids (sphingosine, sphinganine, sphingosine-1-phosphate and ceramide) in human fibroids and pair-matched healthy uterus tissue. We demonstrated that, in uterine leiomyomas, the contents of sphingosine, sphinganine, sphingosine-1-phosphate and ceramide remains quite constant. However, a trend towards elevation of ceramide and simultaneous reduction of sphingosine-1 phosphate levels was also noticed. Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1α/AMPK activation. In conclusion, rather modest changes in sphingolipids are correlated with the activation of PTEN and MAPK(ERK1/2) signaling proteins in human uterine leiomyomas.
在本研究中，我们试图调查人类子宫肌瘤和配对的健康子宫组织中鞘脂（鞘氨醇、二氢鞘氨醇、鞘氨醇-1-磷酸和神经酰胺）的含量。我们证明，在子宫平滑肌瘤中，鞘氨醇、二氢鞘氨醇、鞘氨醇-1-磷酸和神经酰胺的含量保持相当稳定。然而，也注意到神经酰胺有升高趋势，同时鞘氨醇-1-磷酸水平降低。此外，在子宫平滑肌瘤中，我们发现PTEN和MAPK（ERK1/2）信号通路均有相关激活，AKT活性仅有微小变化，且相对缺乏HIF-1α/AMPK激活。总之，鞘脂的变化相当适度，与人类子宫平滑肌瘤中PTEN和MAPK（ERK1/2）信号蛋白的激活相关。
