Taylor C V, Letarte M, Lye S J
Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Am J Obstet Gynecol. 1996 Aug;175(2):411-9. doi: 10.1016/s0002-9378(96)70155-2.
Our purpose was to examine the pattern of integrin and cadherin expression in the normal human uterus and uterine leiomyomas.
Nonpathologic myometrium and endometrium and uterine leiomyoma tissues were collected during hysterectomy. The pattern of integrin and cadherin expression displayed by these tissues was assessed by use of immunohistochemical staining. A transformed leiomyoma cell line was assessed for expression of integrins and cadherins with flow cytometry.
The human myometrium was found to express numerous integrins and cadherins in a cell-specific manner, differing among smooth muscle cells, stromal cells, and endothelial cells. An identical pattern was seen in uterine leiomyomas. In contrast to the endometrium, expression of integrins and cadherins in the myometrium remained constant throughout the menstrual cycle.
This article characterizes the expression of integrins and cadherins in the human uterus. In contrast to many tumors, the growth and development of leiomyomas are not associated with a fundamental change in expression of these cell adhesion molecules. The mechanisms regulating expression of integrins in myometrium and endometrium must be different.
我们的目的是研究整联蛋白和钙黏蛋白在正常人体子宫及子宫平滑肌瘤中的表达模式。
在子宫切除术中收集非病理性子宫肌层、子宫内膜及子宫平滑肌瘤组织。通过免疫组织化学染色评估这些组织中整联蛋白和钙黏蛋白的表达模式。利用流式细胞术评估一种转化的平滑肌瘤细胞系中整联蛋白和钙黏蛋白的表达。
发现人体子宫肌层以细胞特异性方式表达多种整联蛋白和钙黏蛋白，在平滑肌细胞、基质细胞和内皮细胞中有所不同。子宫平滑肌瘤中也观察到相同的模式。与子宫内膜不同，子宫肌层中整联蛋白和钙黏蛋白的表达在整个月经周期中保持恒定。
本文描述了整联蛋白和钙黏蛋白在人体子宫中的表达情况。与许多肿瘤不同，平滑肌瘤的生长和发展与这些细胞黏附分子表达的根本变化无关。调节子宫肌层和子宫内膜中整联蛋白表达的机制必定不同。
