Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Bioessays. 2013 Jan;35(1):23-7. doi: 10.1002/bies.201200138.
After viral entry into the cell, the nuclear envelope poses a major cellular barrier that needs to be overcome upon adaptation of highly pathogenic avian influenza viruses (HPAIV) to the new host. To ensure efficient viral transcription and replication in the nucleus of the host cell, the viral polymerase complex of avian influenza viruses needs to switch from recognition of avian to mammalian components of the nuclear import machinery. Recent evidence suggests that influenza viruses have evolved different mechanisms to utilize importin-α isoforms as components of this machinery, bridging pre- and post-nuclear import on both sides of the nuclear envelope.
病毒进入细胞后，核膜成为细胞的主要障碍，高致病性禽流感病毒（HPAIV）需要适应新宿主才能克服这一障碍。为了确保病毒在宿主细胞的核内有效转录和复制，禽流感病毒的聚合酶复合物需要从识别禽细胞的核输入机制成分转变为识别哺乳动物的核输入机制成分。最近的证据表明，流感病毒已经进化出不同的机制来利用导入蛋白-α 异构体作为该机制的组成部分，在核膜的两侧桥接核输入的前后过程。
