Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
Vaccine. 2012 Dec 7;30(51):7353-8. doi: 10.1016/j.vaccine.2012.04.085. Epub 2012 May 29.
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
与其他 RNA 病毒不同，甲型流感病毒在感染细胞的细胞核中转录和复制其基因组。因此，病毒核糖核蛋白复合物（RNP）及其新合成的蛋白亚基必须与宿主核输入机制相互作用。在这篇综述中，我们讨论了病毒如何利用核输入途径来允许 RNP 在细胞核中进行受调控和伴侣介导的组装，并描述了输入机制本身如何成为宿主嗜性的决定因素。
