钙黏蛋白 11 在滑膜关节形成和类风湿关节炎病理中的作用。
Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology.
机构信息
Department of Anatomy, Tissue Engineering Research Center of Chongqing, The Third Military Medical University, Gaotanyan Street No. 30, Chongqing, 400038, China.
出版信息
Mod Rheumatol. 2013 Nov;23(6):1037-44. doi: 10.1007/s10165-012-0806-7. Epub 2012 Dec 14.
Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. Cadherin-11 is involved in the function of embryonic development, tissue morphogenesis, tumor invasion and metastasis, and signal transduction. This review summarizes the function of cadherin-11 in synovial joint formation and rheumatoid arthritis (RA), including its relative function with bone and cartilage development and growth plate, synovial, and tendon formation. The role of cadherin-11 in RA is also discussed, both in fibroblasts inflammation and fibroblast-like synoviocyte (FLSs) migration and invasion. The potential of anti-cadherin-11 therapy for RA is introduced in comparison with the other current RA therapies.
钙黏蛋白 11 是一种经典的钙黏蛋白黏附分子，介导同质细胞间的黏附。钙黏蛋白 11 参与胚胎发育、组织形态发生、肿瘤侵袭和转移以及信号转导等功能。本综述总结了钙黏蛋白 11 在滑膜关节形成和类风湿关节炎（RA）中的作用，包括其与骨和软骨发育以及生长板、滑膜和肌腱形成的相对功能。还讨论了钙黏蛋白 11 在 RA 中的作用，包括成纤维细胞炎症以及成纤维样滑膜细胞（FLS）迁移和侵袭。并与其他当前的 RA 治疗方法相比，介绍了抗钙黏蛋白 11 治疗 RA 的潜力。
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