Carl U M, Beck-Bornholdt H P, Baumann M, Lorenzen J, Vogler H
Institute of Biophysics and Radiobiology, University of Hamburg, F.R.G.
Int J Radiat Oncol Biol Phys. 1990 Apr;18(4):883-6. doi: 10.1016/0360-3016(90)90412-d.
Rhabdomyosarcoma R1H of the rat was excised aiming for a complete macroscopic local excision. Adjuvant radiotherapy was performed from the third postoperative day on. Former tumor sites were locally irradiated with 200 kVp X rays 4 times per week over a period of 6 weeks. Total doses of 0, 15, 30, 45 and 60 Gy were applied. The tumor volume was measured and the time to regrow to initial volume was assessed. The results were compared to the effect of a standard radiotherapy alone with 30 fractions of 2 Gy applied within 6 weeks. All tumors recurred despite of the irradiation treatment. At high total doses (greater than 30 Gy), adjuvant radiotherapy was found to improve short term tumor response considerably, whereas no positive effect was seen at low doses. After a total dose of 60 Gy and long time intervals after start of treatment, radiotherapy alone and a combination of surgery and radiotherapy seem to be isoeffective in our tumor system.
对大鼠的横纹肌肉瘤R1H进行切除，目标是实现宏观上的局部完整切除。术后第三天开始进行辅助放疗。对原肿瘤部位进行局部照射，采用200 kVp的X射线，每周照射4次，持续6周。分别给予0、15、30、45和60 Gy的总剂量。测量肿瘤体积，并评估肿瘤重新生长至初始体积所需的时间。将结果与在6周内给予30次每次2 Gy的标准单纯放疗效果进行比较。尽管进行了放疗，所有肿瘤均复发。在高总剂量（大于30 Gy）时，发现辅助放疗可显著改善短期肿瘤反应，而低剂量时未见积极效果。在给予60 Gy的总剂量且治疗开始后经过较长时间间隔后，在我们的肿瘤系统中，单纯放疗以及手术与放疗联合似乎具有同等疗效。
