Somers C J, O'Connor J
The Drug Treatment Centre Board, McCarthy Centre, Dublin.
Ir Med J. 2012 Oct;105(9):295-8.
Retrospective study of urinary heroin outcomes of a cohort (123) of patients commenced on a methadone treatment program. Significantly poorer outcomes were associated with urines positive for cocaine (OR 0.69 CI 0.59-0.81) benzodiazepines (OR 0.7 CI 0.53-0.93) with prescribing of low dose methadone (OR 0.65 CI 0.48-0.87), with urines positive for heroin at time of admission (OR 0.74 CI 0.56-0.97) and with behavioural sanctions (OR 0.8, CI 0.65-0.98). Improved outcomes were associated with granting of take away methadone (OR 1.34 CI 1.1-1.62). with an indication of improved outcomes associated with alcohol positive urines (OR 1.34 CI 0.95-1.9) and increased duration of clinic attendance (OR 1.21 CI 0.99-1.47). On multiple regression analysis low dose methadone (0.07 CI 0.01-0.33) prescribing remained negatively associated with urine heroin outcomes.
对123名开始接受美沙酮治疗方案的患者队列的尿样中 heroin 检测结果进行回顾性研究。可卡因尿检呈阳性（比值比0.69，置信区间0.59 - 0.81）、苯二氮䓬类药物尿检呈阳性（比值比0.7，置信区间0.53 - 0.93）、低剂量美沙酮处方（比值比0.65，置信区间0.48 - 0.87）、入院时 heroin 尿检呈阳性（比值比0.74，置信区间0.56 - 0.97）以及行为制裁（比值比0.8，置信区间0.65 - 0.98）与显著较差的结果相关。改善的结果与给予可外带美沙酮（比值比1.34，置信区间1.1 - 1.62）、酒精尿检呈阳性提示结果改善（比值比1.34，置信区间0.95 - 1.9）以及门诊就诊时间延长（比值比1.21，置信区间0.99 - 1.47）相关。在多元回归分析中，低剂量美沙酮处方（0.07，置信区间0.01 - 0.33）与尿样中 heroin 检测结果仍呈负相关。
