一种涉及催化不对称色酮的 Povarov 反应：非对映选择性和对映选择性构建螺[吲哚啉-3,2'-喹啉]骨架。
A catalytic asymmetric isatin-involved Povarov reaction: diastereo- and enantioselective construction of spiro[indolin-3,2'-quinoline] scaffold.
机构信息
School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, China.
出版信息
Org Lett. 2013 Jan 4;15(1):128-31. doi: 10.1021/ol303154k. Epub 2012 Dec 14.
PMID:23240812
Abstract
The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2'-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).
摘要
首次建立了手性催化靛红参与的 Povarov 反应。该方法为获得具有两个季碳手性中心的高对映选择性和非对映选择性（所有 dr 值＞99:1，ee 值高达 97%）的手性螺[吲哚啉-3,2'-喹啉]骨架提供了一种前所未有的方法。
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