碘化物/H₂O₂ 催化的分子内氧化胺化反应合成 3,2'-吡咯烷基螺[吲哚啉-2,3'-氧吲哚]。
Iodide/H₂O₂ Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles.
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Molecules. 2018 Sep 5;23(9):2265. doi: 10.3390/molecules23092265.
An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2'-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant.
碘化铵/过氧化氢介导的 3-氨烷基-2-氧吲哚的分子内氧化胺化反应得以实现，以中等至较高收率得到相应的 3,2'-吡咯烷基螺[吲哚啉-2,3'-氧吲哚]及其 6-或 7-元类似物。该无金属反应条件温和、无毒，且使用毒性较小、易于处理的过氧化氢作为清洁氧化剂。
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