Department of Dermatology, Tokyo Women's Medical University , Tokyo , Japan.
J Dermatolog Treat. 2014 Dec;25(6):507-9. doi: 10.3109/09546634.2012.757284. Epub 2013 Feb 24.
The oral tetracyclines, especially minocycline hydrochloride, are often used as an effective treatment for perioral dermatitis; however, they are sometimes difficult to use, especially in children, because of the side effects.
The effectiveness of β-lactam antibiotics was evaluated in three cases of perioral dermatitis.
Three Japanese patients with perioral dermatitis were treated with cefcapene pivoxil hydrochloride hydrate per os 100-300 mg/day. They were one girl (aged 10 years) and two adult women (aged 32 and 37 years respectively). One of the adult patients had a past history of Meniere's disease and the other had had a side effect, vertigo, from minocycline hydrochloride treatment. The presence of fusobacteria before and after the treatment was examined using the tape-stripping toluidine blue method.
These patients showed the improvement in 1-2 weeks and were much improved or cured after 2-5 weeks. No side effects were found during the treatment. Fusobacteria were positive before treatment but became negative after the treatment in all of them.
The β-lactam antibiotics might be a useful treatment for perioral dermatitis, especially in cases who cannot take tetracyclines.
口服四环素类药物，尤其是盐酸米诺环素，常被用作治疗口周皮炎的有效药物；但由于其副作用，有时难以使用，尤其是在儿童中。
评估β-内酰胺类抗生素在三例口周皮炎患者中的疗效。
我们对 3 例口周皮炎患者使用头孢卡品匹肟盐酸盐口服 100-300mg/天进行治疗。这 3 例患者分别为 1 名女孩（10 岁）、2 名成年女性（分别为 32 岁和 37 岁）。其中 1 名成年患者有梅尼埃病病史，另 1 名有盐酸米诺环素治疗引起的眩晕副作用。使用胶带撕除法甲苯胺蓝染色法在治疗前后检查梭杆菌的存在情况。
这些患者在 1-2 周内得到改善，在 2-5 周后得到明显改善或治愈。治疗期间未发现任何副作用。在所有患者中，治疗前梭杆菌均为阳性，治疗后均转为阴性。
β-内酰胺类抗生素可能是治疗口周皮炎的一种有效方法，特别是对于不能服用四环素类药物的患者。
