Takiwaki H, Tsuda H, Arase S, Takeichi H
Department of Dermatology, The University of Tokushima School of Medicine, Tokushima, Japan.
Clin Exp Dermatol. 2003 Sep;28(5):531-4. doi: 10.1046/j.1365-2230.2003.01349.x.
Although often associated with overuse of topical corticosteroids, perioral dermatitis seems to develop seldom in patients with typical seborrhoeic dermatitis in spite of long-term application of corticosteroids. In order to compare the profiles of intrafollicular microorganisms in the lesions of perioral and seborrhoeic dermatitis, tape-stripped samples were obtained from eight lesions of perioral dermatitis, 10 lesions of seborrhoeic dermatitis, and the perioral skin of 31 normal subjects. After staining with Toluidine blue, resident microorganisms on plucked hair roots were evaluated microscopically. In all patients with perioral dermatitis and two normal subjects, 20-70% of sample hairs were positive for fusiform bacteria regarded as fusobacteria. Malassezia-positive hairs were rarely seen in these cases. Seborrhoeic dermatitis showed the opposite results. Perioral dermatitis may tend to develop under fusiform-bacteria-rich conditions, rather than Malassezia-rich conditions as in the case of seborrhoeic dermatitis.
尽管口周皮炎常与外用糖皮质激素的过度使用有关，但典型脂溢性皮炎患者即使长期使用糖皮质激素，口周皮炎似乎也很少发生。为了比较口周皮炎和脂溢性皮炎皮损中毛囊内微生物的情况，从8例口周皮炎皮损、10例脂溢性皮炎皮损以及31名正常受试者的口周皮肤获取胶带剥离样本。用甲苯胺蓝染色后，在显微镜下评估拔除毛发根部的常驻微生物。在所有口周皮炎患者和两名正常受试者中，20%至70%的样本毛发中梭形菌呈阳性，这些梭形菌被认为是梭杆菌。在这些病例中很少见到马拉色菌阳性的毛发。脂溢性皮炎则呈现相反的结果。口周皮炎可能倾向于在富含梭形菌的条件下发生，而不是像脂溢性皮炎那样在富含马拉色菌的条件下发生。
