Division of Immunology and Infectious Disease, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.
J Perinat Med. 2013 May;41(3):277-82. doi: 10.1515/jpm-2012-0189.
To document racial disparity in an immune modulator, hyaluronan (HA), an antimicrobial, histone H2B (H2B), and an antioxidant, superoxide dismutase (SOD) in amniotic fluid (AF) from African-American (AA) and Caucasian (C) subjects with spontaneous preterm birth (PTB).
In a case (PTB) control (term) study, AF samples were analyzed for HA, H2B and SOD by ELISA. Differences in analyte concentrations between races were documented and a secondary analysis based on histologic chorioamnionitis (HC) was also performed.
No differences in the median HA, H2B and SOD were seen between cases and controls. AA cases had lower HA but higher H2B and SOD than controls. Analyte concentrations were not different between C cases and controls. AA samples at term had lower H2B and SOD compared to C samples at term. Cases with HC showed higher H2B and SOD.
We report ethnic disparity in AF antimicrobial, immune mediator and antioxidant factors. Dysregulated AF production of HA, H2B and SOD was associated with PTB in AA, not in C, suggesting an overwhelming inflammatory response in AA PTB, whereas inflammation is likely a secondary phenomenon in C PTB.
记录在非裔美国人和高加索人（C）自发性早产（PTB）患者的羊水（AF）中，免疫调节剂透明质酸（HA）、抗菌肽组蛋白 H2B（H2B）和抗氧化剂超氧化物歧化酶（SOD）的种族差异。
在病例（PTB）对照（足月）研究中，通过 ELISA 分析 AF 样本中的 HA、H2B 和 SOD。记录种族之间分析物浓度的差异，并进行基于组织学绒毛膜羊膜炎（HC）的二次分析。
病例和对照组之间的 HA、H2B 和 SOD 中位数均无差异。AA 病例的 HA 水平较低，但 H2B 和 SOD 水平较高。C 病例与对照组之间的分析物浓度没有差异。足月的 AA 样本的 H2B 和 SOD 水平低于足月的 C 样本。HC 病例的 H2B 和 SOD 水平较高。
我们报告了 AF 抗菌肽、免疫调节剂和抗氧化剂因子的种族差异。HA、H2B 和 SOD 的 AF 产生失调与 AA 的 PTB 相关，而与 C 无关，提示 AA 的 PTB 存在压倒性的炎症反应，而炎症在 C 的 PTB 中可能是继发现象。
