Menon Ramkumar, Camargo M Constanza, Thorsen Poul, Lombardi Salvatore J, Fortunato Stephen J
Perinatal Research Center of the Women's Health Research and Education Foundation, Women's Hospital at the Centennial Medical Center, Nashville, TN 37203, USA.
Am J Obstet Gynecol. 2008 Jan;198(1):77.e1-7. doi: 10.1016/j.ajog.2007.06.071.
This study examined the differences in the inflammatory cytokine interleukin (IL)-6 and the immunoinhibitory cytokine IL-10 in the amniotic fluid of black and white women in spontaneous preterm birth.
In this study, 321 amniotic fluids from cases (preterm birth 36 or fewer weeks' gestation) and controls (normal term delivery longer than 37 weeks' gestation) were collected (147 cases [49 blacks and 98 whites] and 174 controls [85 blacks and 89 whites]) at the time of active labor. IL-6 and IL-10 concentrations were measured by immunoassays. Using normal-term delivery as controls, logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) for preterm birth.
A significant difference in IL-6 concentration was observed in white cases (cases: 3773 pg/mL; controls: 1682 pg/mL; P = .0003), compared with controls, but not in blacks (cases: 2042 pg/mL; controls: 2366 pg/mL; P = .6). In a combined multivariable analysis, when the highest and the lowest quartiles of IL-6 were compared in whites, the ORs (95% CI) for preterm birth across quartiles were 1.74 (0.62-4.88), 1.09 (0.39-3.02), and 5.68 (2.15-15.0). No such association was found in blacks. IL-10 concentration was not different between cases and controls in either race.
Race-specific associations exist between IL-6 but not IL-10 concentration and preterm birth. Elevated IL-6 concentrations are associated with preterm birth in whites but not blacks.
本研究探讨了自然早产的黑人与白人女性羊水中炎性细胞因子白细胞介素（IL）-6和免疫抑制细胞因子IL-10的差异。
本研究在活跃分娩时收集了321例羊水样本（孕周36周及以下早产）和对照样本（孕周超过37周足月分娩）（147例[49例黑人、98例白人]和174例对照[85例黑人、89例白人]）。通过免疫测定法测量IL-6和IL-10浓度。以足月分娩作为对照，采用逻辑回归模型估计早产的比值比（OR）和95%置信区间（CI）。
与对照组相比，白人病例的IL-6浓度存在显著差异（病例组：3773 pg/mL；对照组：1682 pg/mL；P = 0.0003），而黑人则无差异（病例组：2042 pg/mL；对照组：2366 pg/mL；P = 0.6）。在综合多变量分析中，比较白人中IL-6的最高和最低四分位数时，各四分位数早产的OR（95%CI）分别为1.74（0.�2 - 4.88）、1.09（0.39 - 3.02）和5.68（2.15 - 15.0）。黑人中未发现此类关联。两种族的病例组和对照组之间IL-10浓度均无差异。
IL-6浓度而非IL-10浓度与早产之间存在种族特异性关联。IL-6浓度升高与白人早产相关，与黑人无关。
