Botero Luz E, Toro Andrés E, Patiño Alber J, Salazar Guillermo, Rodríguez Juan C, Suárez-Escudero Juan C, Alarcón Gustavo A, Corcimaru Ana, Osorio Cristina, Jeong Joseph S Y, Alzate Oscar
Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia.
Biomedica. 2012 Jun;32(2):239-51. doi: 10.1590/S0120-41572012000300012.
Alzheimer's disease is a multifactorial disease affecting approximately twenty million people worldwide. Numerous variables are associated with increased risk of developing this severe neurological disorder. Among the risk factors, diabetes mellitus, and the ε4 isoform of the APOE gene have been amply demonstrated as increasing the risk of developing this disease.
To determine if a correlation exists between APOE genotype, diabetes mellitus and Alzheimer's disease.
Clinical studies were carried out by surveying the clinical histories in a group of patients in the province of Antioquia, Colombia. Forty-three Alzheimer's patients were compared with 43 control subjects, paired by age and gender. Commercially available methods were used to determine whether the patients had diabetes, and restriction enzyme-based genotyping was used to determine the APOE genotypes.
The most common non-neurological comorbidities were: arterial hypertension, acute myocardial infarction, chronic obstructive pulmonary disease and hypothyroidism. From the many variables investigated, two were conclusive: (1) the presence of Alzheimer's disease was higher in patients with diabetes mellitus, and (2) no correlation between late-onset sporadic Alzheimer's disease and APOE was found in the target population.
To detect any association with the APOE genotype, a study involving much a larger population samples must be undertaken.
阿尔茨海默病是一种多因素疾病，全球约有2000万人受其影响。许多变量与患这种严重神经疾病的风险增加有关。在风险因素中，糖尿病和APOE基因的ε4异构体已被充分证明会增加患此病的风险。
确定APOE基因型、糖尿病与阿尔茨海默病之间是否存在关联。
通过调查哥伦比亚安蒂奥基亚省一组患者的临床病史进行临床研究。将43例阿尔茨海默病患者与43例对照受试者进行比较，对照受试者按年龄和性别配对。使用市售方法确定患者是否患有糖尿病，并使用基于限制性内切酶的基因分型来确定APOE基因型。
最常见的非神经合并症为：动脉高血压、急性心肌梗死、慢性阻塞性肺疾病和甲状腺功能减退。在研究的众多变量中，有两个结论性变量：（1）糖尿病患者患阿尔茨海默病的比例更高；（2）在目标人群中未发现迟发性散发性阿尔茨海默病与APOE之间存在相关性。
为了检测与APOE基因型的任何关联，必须进行一项涉及更多大样本量人群的研究。
