Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Pathol Oncol Res. 2013 Jul;19(3):413-9. doi: 10.1007/s12253-012-9594-9. Epub 2012 Dec 16.
Medulloblastomas are highly invasive tumors which are generally disseminated at the time of diagnosis. High and continued morbidity and mortality have prompted the search for new biologic markers that might be used for targeted therapy to minimise treatment related side effects. In this work, we studied the positive expression of survivin in medulloblastoma and investigated its relation to clinical, pathologic data and survival. Tumor tissue specimens from 47 patients with medulloblastoma who underwent primary surgical treatment from June 2002 to June 2006 at the Mansoura university hospital, Egypt were collected. Paraffin sections of all samples were submitted for immunohistochemistry using anti-survivin antibody. The relation between the percentage of positive survivin cells with clinical, pathological and survival data was evaluated.
In 47 cancer tissue specimens, one case large-cell-anaplastic (1.12 %), tweleve cases desmoplastic (25.53 %) and 34 cases classic medulloblastomas (72.34 %). The immunohistochemical expression of survivin was nulear with moderate intensity. It does not correlate with either age or sex. There was a significant negative correlation of survivin expression with survival (p < 0.001), where negative survivin immunostaining was associated with prolonged overall and disease free survival, while survivin expression was associated with shortened survival.
Survivin expression correlate with the clinical outcome with poor prognosis and could be a potential predictive factor for recurrence or metastasis.
成神经管细胞瘤是高度侵袭性肿瘤，通常在诊断时就已扩散。高且持续的发病率和死亡率促使人们寻找新的生物标志物，以便进行靶向治疗，从而最大限度地减少治疗相关的副作用。在这项工作中，我们研究了成神经管细胞瘤中 survivin 的阳性表达，并研究了其与临床、病理数据和生存的关系。从 2002 年 6 月至 2006 年 6 月，在埃及曼苏拉大学医院接受初次手术治疗的 47 例成神经管细胞瘤患者的肿瘤组织标本被收集。所有样本的石蜡切片均使用抗 survivin 抗体进行免疫组织化学染色。评估了阳性 survivin 细胞的百分比与临床、病理和生存数据之间的关系。
在 47 例癌症组织标本中，1 例大细胞-间变性（1.12%），12 例促结缔组织增生性（25.53%）和 34 例经典成神经管细胞瘤（72.34%）。 survivin 的免疫组织化学表达为核中等强度。它与年龄或性别无关。 survivin 表达与生存呈显著负相关（p<0.001），其中 survivin 免疫染色阴性与总生存期和无病生存期延长相关，而 survivin 表达与生存期缩短相关。
survivin 表达与临床结果相关，预后不良，可能是复发或转移的潜在预测因子。
