G Guralarasan, Bharti Shreekant, Jha Vikas C, Nigam Jitendra S, Ganesh R Abhirami, Bhadani Punam
Pathology and Lab Medicine, All India Institute of Medical Sciences, Patna, Patna, IND.
Neurosurgery, All India Institute of Medical Sciences, Patna, Patna, IND.
Cureus. 2024 Jul 29;16(7):e65627. doi: 10.7759/cureus.65627. eCollection 2024 Jul.
Medulloblastoma (MB) is a common malignant intracranial neoplasms in children. The treatment and prognosis of this tumor depends on histology and molecular subtypes. Survivin, implicated in various malignancies, may hold prognostic significance. We investigated survivin and p53 immunoreactivity in different histological subtypes in 20 MB cases from January 2018 to June 2021. Immunohistochemistry revealed survivin expression in 75% (15/20) of cases, with cytoplasmic (10 cases), nuclear (four cases), or combined expression (one case). p53 nuclear expression was present in 35% (7/20) of cases. Classical variant MB exhibited predominant p53 and cytoplasmic survivin expression. Given the association of survivin and p53 expression with poor prognosis, especially in the prevalent classical variant, targeted therapies may hold promise for MB treatment advancement.
髓母细胞瘤（MB）是儿童常见的恶性颅内肿瘤。该肿瘤的治疗和预后取决于组织学和分子亚型。Survivin与多种恶性肿瘤相关，可能具有预后意义。我们调查了2018年1月至2021年6月期间20例MB病例中不同组织学亚型的Survivin和p53免疫反应性。免疫组织化学显示，75%（15/20）的病例中有Survivin表达，其中细胞质表达（10例）、细胞核表达（4例）或联合表达（1例）。35%（7/20）的病例中有p53细胞核表达。经典变异型MB表现为主要的p53和细胞质Survivin表达。鉴于Survivin和p53表达与不良预后相关，尤其是在常见的经典变异型中，靶向治疗可能为MB治疗的进展带来希望。
