Department of Internal Medicine, Mbarara Regional Referral Hospital, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Am J Trop Med Hyg. 2013 Jan;88(1):127-31. doi: 10.4269/ajtmh.2012.12-0447. Epub 2012 Dec 12.
We validated a handheld point-of-care lactate (POCL) monitor's ability to measure lactate in cerebrospinal fluid (CSF) and diagnose bacterial meningitis in Uganda. There was a strong linear correspondence between POCL and standard laboratory lactate test results (R(2) = 0.86; P < 0.001). For 145 patients with clinical meningitis, the area under the receiver operating characteristic curve for the prediction of bacterial meningitis by CSF POCL was 0.92 (95% confidence interval = 0.85-0.99, P < 0.001). A CSF POCL concentration of 7.7 mmol/L provided 88% sensitivity and 90% specificity for the diagnosis of bacterial meningitis. CSF POCL testing had excellent use in the diagnosis of bacterial meningitis, and it may be useful where CSF analyses are delayed or laboratory infrastructure is limited.
我们验证了手持式即时乳酸（POCL）监测仪测量脑脊液（CSF）中乳酸和诊断乌干达细菌性脑膜炎的能力。POCL 与标准实验室乳酸检测结果之间存在很强的线性对应关系（R²=0.86；P<0.001）。对于 145 例有临床脑膜炎的患者，CSF POCL 预测细菌性脑膜炎的受试者工作特征曲线下面积为 0.92（95%置信区间为 0.85-0.99，P<0.001）。CSF POCL 浓度为 7.7mmol/L 时，对细菌性脑膜炎的诊断具有 88%的敏感性和 90%的特异性。CSF POCL 检测在细菌性脑膜炎的诊断中具有出色的应用价值，在 CSF 分析延迟或实验室基础设施有限的情况下可能有用。
