Smyth J B, Wang J H, Barlow R M, Humphreys D J, Robins M, Stodulski J B
Department of Veterinary Pathology, Royal Veterinary College, Hatfield, Herts, U.K.
J Comp Pathol. 1990 Feb;102(2):197-209. doi: 10.1016/s0021-9975(08)80125-9.
The toxic effects of 5 mg per kg body weight of selenium given as sodium selenite orally or parenterally to growing lambs were examined. There was considerable individual variation in both susceptibility to intoxication and the degree of pathological change displayed. The results affirm the previously reported deleterious effects on the cardiovascular, respiratory and urinary systems and highlight damage to secondary lymphoid tissue in various organs. The use of a histochemical method for detecting selenium bonds demonstrated correlation between the density of reaction-product and histopathological changes within tissues, and showed the distribution of selenium in other tissues in which the gross and histopathological findings were non-specific or minimal.
研究了以亚硒酸钠的形式，按每千克体重5毫克的剂量经口或非经口给予生长中的羔羊时硒的毒性作用。在对中毒的易感性和所表现出的病理变化程度方面均存在相当大的个体差异。结果证实了先前报道的对心血管、呼吸和泌尿系统的有害作用，并突出了对各器官继发性淋巴组织的损害。使用一种检测硒键的组织化学方法证明了反应产物密度与组织内组织病理学变化之间的相关性，并显示了硒在其他组织中的分布情况，而在这些组织中大体和组织病理学发现是非特异性的或很轻微的。
