Blodgett D J, Bevill R F
Vet Hum Toxicol. 1987 Jun;29(3):233-6.
Acute selenium (Se) toxicosis was evaluated in 20 female crossbred sheep, 8 to 14 mo of age. Five groups of 4 sheep each were given 0.4, 0.6, 0.7, 0.8, or 1.0 mg Se/kg body weight IM. The LD50 for sodium selenite was 0.7 mg Se/kg body weight with a standard error of 0.035 over a 192 hr observation period. The most evident clinical signs were dyspnea and depression. At necropsy, the most consistent lesions in animals which received 0.7, 0.8, and 1.0 mg Se/kg body weight were edematous lungs and pale mottled hearts. Highest tissue Se concentrations in declining order were found in the liver, kidney and heart.
对20只8至14月龄的雌性杂交绵羊进行了急性硒中毒评估。将20只羊分为5组，每组4只，分别肌肉注射0.4、0.6、0.7、0.8或1.0毫克硒/千克体重。在192小时的观察期内，亚硒酸钠的半数致死量为0.7毫克硒/千克体重，标准误差为0.035。最明显的临床症状是呼吸困难和抑郁。尸检时，接受0.7、0.8和1.0毫克硒/千克体重的动物最一致的病变是肺水肿和心脏苍白斑驳。组织中硒浓度由高到低依次为肝脏、肾脏和心脏。
