Gupta Samir, Donn Steven M
University Hospital of North Tees and Durham University, Hardwick Road, Stockton-on-Tees, Cleveland, OH TS19 8PE, UK.
Crit Care Res Pract. 2012;2012:278483. doi: 10.1155/2012/278483. Epub 2012 Dec 3.
Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical evidence.
二十多年来,表面活性剂替代疗法一直是治疗呼吸窘迫综合征早产儿的主要手段。在大多数情况下,表面活性剂通过气管内给药,随后进行机械通气。近年来,对无创通气的兴趣日益浓厚,催生了新的给药方法。本文将综述这些技术及相关临床证据。