用于治疗肺部疾病的表面活性剂替代疗法的递送与性能。
Delivery and performance of surfactant replacement therapies to treat pulmonary disorders.
作者信息
El-Gendy Nashwa, Kaviratna Anubhav, Berkland Cory, Dhar Prajnaparamita
机构信息
Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
出版信息
Ther Deliv. 2013 Aug;4(8):951-80. doi: 10.4155/tde.13.72.
Abstract
Lung surfactant is crucial for optimal pulmonary function throughout life. An absence or deficiency of surfactant can affect the surfactant pool leading to respiratory distress. Even if the coupling between surfactant dysfunction and the underlying disease is not always well understood, using exogenous surfactants as replacement is usually a standard therapeutic option in respiratory distress. Exogenous surfactants have been extensively studied in animal models and clinical trials. The present article provides an update on the evolution of surfactant therapy, types of surfactant treatment, and development of newer-generation surfactants. The differences in the performance between various surfactants are highlighted and advanced research that has been conducted so far in developing the optimal delivery of surfactant is discussed.
摘要
肺表面活性物质对一生的最佳肺功能至关重要。表面活性物质的缺乏或不足会影响表面活性物质池，导致呼吸窘迫。即使表面活性物质功能障碍与潜在疾病之间的关联并不总是完全清楚，但使用外源性表面活性物质作为替代通常是治疗呼吸窘迫的标准选择。外源性表面活性物质已在动物模型和临床试验中得到广泛研究。本文提供了表面活性物质治疗的进展、表面活性物质治疗类型以及新一代表面活性物质发展的最新情况。文中强调了各种表面活性物质之间性能的差异，并讨论了迄今为止在开发表面活性物质最佳给药方式方面所进行的前沿研究。
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2
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J Aerosol Med Pulm Drug Deliv. 2013 Dec;26(6):370-9. doi: 10.1089/jamp.2012.0996. Epub 2013 Feb 19.
3
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Crit Care Res Pract. 2012;2012:278483. doi: 10.1155/2012/278483. Epub 2012 Dec 3.
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