癌症患者体内的人类辅助性T细胞17：是友还是敌？
Human Th17 cells in patients with cancer: Friends or foe?
作者信息
Greten Tim F, Zhao Fei, Gamrekelashvili Jaba, Korangy Firouzeh
机构信息
Gastrointestinal Malignancy Section; Medical Oncology Branch; National Cancer Institute; Bethesda, MD USA.
出版信息
Oncoimmunology. 2012 Nov 1;1(8):1438-1439. doi: 10.4161/onci.21245.
The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.
分泌白细胞介素-17（IL-17）的CD4(+) T（Th17）细胞在癌症中的作用正在深入研究中。我们已经证明，CCR4(+)CCR6(+) Th17细胞不仅在肝细胞癌患者的外周血中增多，而且在体外抑制CD8(+) T细胞功能。这些结果表明，Th17细胞可能在肝细胞癌中发挥免疫抑制功能。
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