Department of Psychology, University of California, Berkeley, California 94720, USA.
Annu Rev Clin Psychol. 2013;9:409-33. doi: 10.1146/annurev-clinpsy-050212-185538. Epub 2012 Dec 10.
Translational research on emotion in schizophrenia has revealed deficits in emotion perception and expression, as well as intact areas, including emotional experience and brain activation in the presence of emotionally evocative material. Yet, a closer look at emotional experience reveals that all is not well in the experience domain. People with schizophrenia have difficulty anticipating emotional events and maintaining or savoring their emotional experiences, as evidenced in behavioral, psychophysiological, and brain imaging studies. Furthermore, people with schizophrenia have difficulty integrating emotion perception with context and reporting on feelings that are differently valenced than presented emotional stimuli. Differences in brain activation are typically observed in areas tightly coupled with cognitive control, such as the dorsolateral prefrontal cortex, and thus the latest research on emotion in schizophrenia explicitly integrates emotion and cognition. Translational research holds promise to identify when in the course of the disorder emotion deficits emerge and to develop more effective interventions for schizophrenia.
精神分裂症的情绪转化研究揭示了在情绪感知和表达方面的缺陷，以及包括情绪体验和在情感唤起材料存在下的大脑激活等完整区域。然而，更仔细地观察情绪体验会发现，在体验领域并非一切都好。精神分裂症患者在预测情绪事件和维持或享受他们的情绪体验方面存在困难，这在行为、心理生理学和脑成像研究中得到了证明。此外，精神分裂症患者难以将情绪感知与情境相结合，并报告与呈现的情绪刺激不同的情感。大脑激活的差异通常在与认知控制紧密耦合的区域中观察到，如背外侧前额叶皮层，因此精神分裂症情绪的最新研究明确地将情绪和认知结合起来。转化研究有望确定在疾病过程中何时出现情绪缺陷，并为精神分裂症开发更有效的干预措施。
