Aga Mitsuharu, Kondo Satoru, Yamada Kazunori, Sawada-Kitamura Seiko, Yagi-Nakanishi Sayaka, Endo Kazuhira, Wakisaka Naohiro, Murono Shigeyuki, Kawano Mitsuhiro, Yoshizaki Tomokazu
Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
Auris Nasus Larynx. 2013 Oct;40(5):514-7. doi: 10.1016/j.anl.2012.11.005. Epub 2012 Dec 13.
Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular glands. He had a history of a Warthin's tumor of the left parotid gland, autoimmune pancreatitis, and an inflammatory abdominal aortic aneurysm. Laboratory tests revealed a high serum IgG4 level. Histological examination of the resected parotid gland showed a Warthin's tumor and a nodule showing severe lymphocytic infiltration containing many IgG4-positive plasma cells. This case shows the possible involvement of Warthin's tumor with IgG4-RD.
免疫球蛋白G4相关性疾病（IgG4-RD）是一种与血清IgG4水平升高及表达IgG4的浆细胞组织浸润相关的炎症性疾病。已有数种与IgG4-RD相关的炎症性疾病被报道。沃辛瘤是一种良性腮腺肿瘤，由嗜酸性上皮细胞和含有具有反应性生发中心的淋巴滤泡的淋巴样间质组成。这是首例描述可能累及IgG4-RD的沃辛瘤病例。患者为一名71岁男性，表现为右侧腮腺及双侧颌下腺肿大。他有左侧腮腺沃辛瘤、自身免疫性胰腺炎及炎性腹主动脉瘤病史。实验室检查显示血清IgG4水平升高。对切除的腮腺进行组织学检查发现一个沃辛瘤和一个结节，该结节显示有严重的淋巴细胞浸润，含有许多IgG4阳性浆细胞。该病例显示沃辛瘤可能累及IgG4-RD。
