Universidade Federal Fluminense/Polo Universitário de Rio das Ostras, Rua Recife s/n, CEP: 28890-000, Rio das Ostras, RJ, Brazil.
Cancer Lett. 2013 Apr 30;331(1):11-7. doi: 10.1016/j.canlet.2012.12.003. Epub 2012 Dec 12.
Human osteopontin is subject to alternative splicing, which generates three isoforms, termed OPNa, OPNb and OPNc. These variants show specific expression and roles in different cell contexts. We present an overview of current knowledge of the expression profile of human OPN splicing isoforms (OPN-SIs), their tissue-specific roles, and the pathways mediating their functional properties in different pathophysiological conditions. We also describe their putative application as biomarkers, and their potential use as therapeutic targets by using antibodies, oligonucleotides or siRNA molecules. This synthesis provides new clues for a better understanding of human OPN splice variants, their roles in normal and pathological conditions, and their possible clinical applications.
人类骨桥蛋白经历选择性剪接，生成三种异构体，分别称为 OPNa、OPNb 和 OPNc。这些变体在不同的细胞环境中表现出特定的表达和作用。我们概述了目前对人类 OPN 剪接异构体（OPN-SIs）表达谱的认识，它们在组织特异性中的作用，以及在不同病理生理条件下介导其功能特性的途径。我们还描述了它们作为生物标志物的潜在应用，以及通过使用抗体、寡核苷酸或 siRNA 分子作为治疗靶点的潜在用途。这一综合研究为更好地理解人类 OPN 剪接变体、它们在正常和病理条件下的作用以及它们可能的临床应用提供了新的线索。
