白血病中的染色体异常。

Chromosome abnormalities in leukemia.

作者信息

Rowley J D

出版信息

Haematol Blood Transfus. 1979;23:43-52. doi: 10.1007/978-3-642-67057-2_5.

Abstract

The consistent occurrence of nonrandom chromosome changes in human malignancies suggests that they are not trivial epiphonomena. Whereas we do not understand their significance at present, one possible role which they may fulfill is to provide the chromosomally aberrant cells with a proliferative advantage as the result of alteration in the number or location of genes related to nucleic acid biosynthesis. The proliferative advantage provided by various chromosome aberrations is likely to differ in patients with different genetic constitutions.

摘要

人类恶性肿瘤中持续出现的非随机染色体变化表明，它们并非微不足道的附带现象。尽管我们目前尚不了解它们的意义，但它们可能发挥的一个作用是，由于与核酸生物合成相关的基因数量或位置发生改变，为染色体异常的细胞提供增殖优势。不同遗传构成的患者中，各种染色体畸变所提供的增殖优势可能有所不同。