Dantey Kossivi, Cooper Kumarasen
Department of Pathology and Laboratory Medicine, Fletcher Allen Health Care/University of Vermont College of Medicine, Burlington, VT 05401, USA.
Int J Surg Pathol. 2013 Aug;21(4):358-62. doi: 10.1177/1066896912470166. Epub 2012 Dec 17.
Limited myxoid areas are usually encountered in solitary fibrous tumor (SFT), but SFT with abundant myxoid stroma has only been reported occasionally. Myxoid SFT is defined as having myxoid changes in 50% or more of the tumor. We review the literature on myxoid SFT and add 3 new cases to those previously described. Microscopically, the lesions were composed of spindle cells arranged in a haphazard or storiform pattern in a cellular and hypocellular myxoid background with thin-walled "staghorn" branching vessels. Atypical features (necrosis, hypercellularity, or increased mitotic figures) were not identified. All cases were positive for CD34 and CD99 and had a benign course with a follow-up ranging from 15 to 70 months. Our review suggests that like classical SFT, myxoid SFT is associated with an indolent clinical course and favorable prognosis. Their recognition is crucial to distinguish a variety of myxoid spindle cell neoplasms with different prognoses and treatment options.
孤立性纤维性肿瘤（SFT）中通常可见局限性黏液样区域，但仅有少量关于富含黏液样间质的SFT的报道。黏液样SFT被定义为肿瘤中50%或更多区域出现黏液样改变。我们回顾了关于黏液样SFT的文献，并在之前描述的病例基础上新增了3例。显微镜下，病变由梭形细胞组成，这些细胞在细胞性和细胞稀少的黏液样背景中呈杂乱或束状排列，伴有薄壁“鹿角状”分支血管。未发现非典型特征（坏死、细胞增多或有丝分裂象增加）。所有病例CD34和CD99均呈阳性，临床过程良性，随访时间为15至70个月。我们的回顾表明，与经典SFT一样，黏液样SFT临床过程惰性，预后良好。对它们的识别对于区分具有不同预后和治疗选择的各种黏液样梭形细胞肿瘤至关重要。
