基于组学的方法揭示鼠疫耶尔森氏菌毒力。
Omics strategies for revealing Yersinia pestis virulence.
机构信息
Beijing Institute of Microbiology and Epidemiology Beijing, China.
出版信息
Front Cell Infect Microbiol. 2012 Dec 13;2:157. doi: 10.3389/fcimb.2012.00157. eCollection 2012.
Abstract
Omics has remarkably changed the way we investigate and understand life. Omics differs from traditional hypothesis-driven research because it is a discovery-driven approach. Mass datasets produced from omics-based studies require experts from different fields to reveal the salient features behind these data. In this review, we summarize omics-driven studies to reveal the virulence features of Yersinia pestis through genomics, trascriptomics, proteomics, interactomics, etc. These studies serve as foundations for further hypothesis-driven research and help us gain insight into Y. pestis pathogenesis.
摘要
组学技术极大地改变了我们研究和理解生命的方式。与传统的基于假设的研究不同，组学是一种基于发现的方法。基于组学的研究产生的大量数据集需要来自不同领域的专家来揭示这些数据背后的显著特征。在这篇综述中，我们总结了组学驱动的研究，通过基因组学、转录组学、蛋白质组学、相互作用组学等揭示了鼠疫耶尔森菌的毒力特征。这些研究为进一步的基于假设的研究奠定了基础，帮助我们深入了解鼠疫耶尔森菌的发病机制。
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