慢性阻塞性肺疾病简述。
A brief review of chronic obstructive pulmonary disease.
机构信息
University of British Columbia Research Laboratories, St Paul's Hospital, Vancouver, British Columbia.
出版信息
Can Respir J. 2012 Nov-Dec;19(6):381-4. doi: 10.1155/2012/496563.
A recent study, based on a combination of multidetector computed tomography scanning of an intact specimen with microcomputed tomography and histological analysis of lung tissue samples, reported that the number of terminal bronchioles were reduced from approximately 44,500/lung pair in control (donor) lungs to approximately 4800/lung pair in lungs donated by individuals with very severe (Global initiative for chronic Obstructive Lung Disease stage 4) chronic obstructive pulmonary disease (COPD) treated by lung transplantation. The present short review discusses the hypothesis that a rapid rate of terminal bronchiolar destruction causes the rapid decline in lung function leading to advanced COPD. With respect to why the terminal bronchioles are targeted for destruction, the postulated mechanisms of this destruction and the possibility that new treatments are able to either prevent or reverse the underlying cause of airway obstruction in COPD are addressed.
最近的一项研究基于对完整标本的多探测器计算机断层扫描，结合微计算机断层扫描和肺组织样本的组织学分析，报告称，终末细支气管的数量从对照组（供体）肺中的每对肺约 44500 个减少到患有非常严重（慢性阻塞性肺疾病全球倡议第 4 阶段）慢性阻塞性肺疾病（COPD）的供体肺中的每对肺约 4800 个。本短评讨论了这样一种假设，即终末细支气管的快速破坏导致肺功能迅速下降，导致 COPD 进展。关于为什么终末细支气管是破坏的目标，提出了这种破坏的机制以及新的治疗方法是否能够预防或逆转 COPD 气道阻塞的根本原因的可能性。
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