Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, USA.
Org Lett. 2013 Jan 4;15(1):58-61. doi: 10.1021/ol303089w. Epub 2012 Dec 18.
A convergent synthesis of the protected C(1)-C(11) fragment 6 of the targeted enantiomer of tedanolide C is described. The key step of the synthesis is the Felkin-Ahn addition of vinyl iodide 7 to aldehyde 8 that proceeds in 80% yield with 4:1 diastereoselectivity.
本文描述了靶向紫杉醇 C 对映异构体的保护的 C(1)-C(11) 片段 6 的收敛性合成。该合成的关键步骤是乙烯基碘化物 7 对醛 8 的 Felkin-Ahn 加成,该加成以 80%的收率和 4:1 的非对映选择性进行。