螺旋星衫鱼素A的C1 - C23片段的合成
Synthesis of the C1-C23 fragment of Spirastrellolide A.
作者信息
Yang Jin-Haek, Liu Jia, Hsung Richard P
机构信息
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705-2222, USA.
出版信息
Org Lett. 2008 Jun 19;10(12):2525-8. doi: 10.1021/ol8008057. Epub 2008 May 17.
PMID:18484725
Abstract
Synthesis of the C1-C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3- anti aldol involving methyl ketone enolate and Mukaiyama conditions.
摘要
描述了螺旋星衫醇A中C1 - C23片段的合成，其特点是采用环状缩醛连接的RCM进行螺环缩酮的立体选择性构建，以及涉及甲基酮烯醇化物和向山条件的1,3 - 反式羟醛反应。
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