Department of Molecular Biology, National Centre of Competence in Research "Frontiers in Genetics," University of Geneva, CH-1211 Geneva-4, Switzerland.
Genes Dev. 2012 Dec 15;26(24):2669-72. doi: 10.1101/gad.210690.112.
In this issue of Genes & Development, Kojima and colleagues (pp. 2724-2736) examined the impact of mRNA poly(A) tail length on circadian gene expression. Their study demonstrates how dynamic changes in transcript poly(A) tail length can lead to rhythmic protein expression, irrespective of whether mRNA accumulation is circadian or constitutive.
在本期《基因与发育》中,Kojima 及其同事(第 2724-2736 页)研究了 mRNA 多聚腺苷酸尾长对生物钟基因表达的影响。他们的研究表明,转录物多聚腺苷酸尾长的动态变化如何导致节律性蛋白质表达,而不论 mRNA 积累是否具有生物钟节律或组成型。