视交叉上核中的血管加压素信使核糖核酸：聚腺苷酸尾长度的日常调节
Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.
作者信息
Robinson B G, Frim D M, Schwartz W J, Majzoub J A
机构信息
Howard Hughes Medical Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
出版信息
Science. 1988 Jul 15;241(4863):342-4. doi: 10.1126/science.3388044.
Daily variation has been found in the length of the polyadenylate tail attached to vasopressin messenger RNA in the suprachiasmatic nuclei, which is the location of an endogenous circadian pacemaker in mammals. No such variation was found in the supraoptic or paraventricular nuclei. This variation in the length of the polyadenylate tail may underlie the circadian rhythm of vasopressin peptide levels in cerebrospinal fluid and is a unique example of a daily rhythm in messenger RNA structure.
已发现，在视交叉上核中，附着于血管加压素信使核糖核酸的聚腺苷酸尾长度存在每日变化，视交叉上核是哺乳动物内源性昼夜节律起搏器的所在位置。在视上核或室旁核中未发现此类变化。聚腺苷酸尾长度的这种变化可能是脑脊液中血管加压素肽水平昼夜节律的基础，并且是信使核糖核酸结构中每日节律的一个独特例子。
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