Animal Health and Veterinary Laboratories Agency, TSE Department, Addlestone, Weybridge, Surrey KT15 3NB, UK.
Vet Rec. 2013 Jan 19;172(3):70. doi: 10.1136/vr.101158. Epub 2012 Dec 18.
Bovine spongiform encephalopathy (BSE) is a prion disease of cattle which was first observed in Great Britain (GB) in 1986. Throughout the subsequent BSE epidemic, cases identified by passive surveillance have shown consistent histopathological, immunohistochemical, biochemical and biological properties. However, since the start of active surveillance in 2001, across Europe and elsewhere, approximately 67 cases with different biochemical characteristics have been identified by Western blotting (WB). These cases fall into two categories; 'H-type' (H-BSE) or 'L-type' (L-BSE), based on the relatively heavy (H-BSE) or light (L-BSE) mass of the unglycosylated band of the prion protein, as compared with WB against that obtained from classical BSE (C-BSE) cases. Here we report the detection and confirmation of the first four L-BSE cases by active surveillance in GB, two of which were born after the reinforced feed ban of 1996 (BARB cases). These four L-BSE cases were found in relatively old cattle (age range; 11-21 years old) and the carcases did not enter the human food chain or animal feed chains.
牛海绵状脑病（BSE）是一种牛朊病毒病，于 1986 年在英国首次观察到。在随后的 BSE 疫情中，通过被动监测发现的病例具有一致的组织病理学、免疫组织化学、生物化学和生物学特性。然而，自 2001 年开始主动监测以来，在欧洲和其他地区，通过 Western blot（WB）已经确定了大约 67 例具有不同生化特征的病例。这些病例分为两类；根据未糖基化朊病毒蛋白条带的相对重（H-BSE）或轻（L-BSE）质量，与从经典 BSE（C-BSE）病例获得的 WB 相比，这些病例分为“H 型”（H-BSE）或“L 型”（L-BSE）。在这里，我们报告了在英国通过主动监测首次发现的前四个 L-BSE 病例，其中两个病例出生于 1996 年强化饲料禁令之后（BARB 病例）。这四个 L-BSE 病例出现在相对较老的牛中（年龄范围为 11-21 岁），这些牛的尸体没有进入人类食物链或动物饲料链。
