从东北缬草根及根茎提取的化合物可预防 PC12 细胞的神经毒性。

Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China.

Molecules. 2012 Dec 18;17(12):15013-21. doi: 10.3390/molecules171215013.

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.

从阿尔茨海默病（AD）有效部位分离出的败酱根和根茎的三种类卡烯型倍半萜，黑穗消旋卡醇 A-C（化合物 1-3），以及 10 种已知化合物 4-13。根据光谱数据确定了 1-3 的结构。我们还研究了化合物 1-13 对淀粉样蛋白-β（Aβ（25-25））诱导的 PC12 细胞神经毒性的保护作用。结果表明，类卡烯型倍半萜 1-4 和木脂素 5-7 可防止 PC12 细胞中 Aβ诱导的毒性。本研究将有助于揭示败酱草治疗 AD 的化学基础。