缬草属植物根中的环烯醚萜及其神经保护作用。
Iridoids from the roots of Valeriana jatamansi and their neuroprotective effects.
机构信息
College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
出版信息
Fitoterapia. 2011 Oct;82(7):1133-6. doi: 10.1016/j.fitote.2011.07.013. Epub 2011 Jul 23.
Three new iridoids, valeriandoids A-C (1-3), together with three known analogues (4-6), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. All the isolated compounds were evaluated for their neuroprotective effects and compounds 1, 3, 4 and 6 showed moderate neuroprotective effects.
从缬草中分离得到了三种新的裂环环烯醚萜类化合物，缬草醇 A-C（1-3），以及三种已知的类似物（4-6）。通过光谱方法（IR、ESIMS、HRESIMS、1D 和 2D NMR）以及与相关化合物的 NMR 数据比较，阐明了它们的结构和相对构型。所有分离得到的化合物都进行了神经保护活性评价，化合物 1、3、4 和 6 表现出中等的神经保护活性。
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