Parker M G
Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, London, UK.
J Reprod Fertil. 1990 Mar;88(2):717-20. doi: 10.1530/jrf.0.0880717.
Steroid hormones regulate rates of transcription of certain genes by binding as a hormone-receptor complex to specific DNA sequences termed steroid-response elements. These elements consist of inverted repeats of the sequence TGTTCT for glucocorticoids, progestagens and androgens and TGACC for oestrogens. Domains for steroid binding, DNA binding and transcriptional activation have been defined in the mouse oestrogen receptor.
类固醇激素通过作为激素 - 受体复合物与特定的DNA序列（称为类固醇反应元件）结合来调节某些基因的转录速率。这些元件由糖皮质激素、孕激素和雄激素的TGTTCT序列的反向重复序列以及雌激素的TGACC序列组成。在小鼠雌激素受体中已确定了类固醇结合、DNA结合和转录激活结构域。
