美国头颈部黏膜黑色素瘤的发病率呈上升趋势。
Rising incidence of mucosal melanoma of the head and neck in the United States.
作者信息
Marcus David M, Marcus Rebecca P, Prabhu Roshan S, Owonikoko Taofeek K, Lawson David H, Switchenko Jeffrey, Beitler Jonathan J
机构信息
Department of Radiation Oncology, Emory University, 1365 Clifton Road NE, Suite AT225, Atlanta, GA 30322, USA ; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
出版信息
J Skin Cancer. 2012;2012:231693. doi: 10.1155/2012/231693. Epub 2012 Dec 2.
Background. While it is established that the incidence of cutaneous melanoma has risen over time in the United States, the incidence trend for mucosal melanoma of the head and neck (MMHN) is unknown. Methods. We used the Surveillance, Epidemiology, and End Results (SEER) database to determine incidence trends for MMHN from 1987 to 2009 in the United States. We determined annual percent change (APC) by weighted least squares and joinpoint regression analysis. Results. MMHN incidence increased from 1987 to 2009 (APC 2.4%; P < 0.01). Nasal cavity lesions increased in incidence (APC 2.7%; P < 0.01) over this duration, while the incidence of non-nasal cavity lesions remained stable. The highest rate of increase was in white females ages 55 to 84 (APC 5.1%; P = 0.01). Conclusions. The incidence of MMHN in the United States has been rising since 1987. This trend is driven primarily by increased incidence of nasal cavity melanomas.
背景。虽然在美国皮肤黑色素瘤的发病率随时间推移有所上升已得到证实，但头颈部黏膜黑色素瘤（MMHN）的发病趋势尚不清楚。方法。我们使用监测、流行病学和最终结果（SEER）数据库来确定1987年至2009年美国MMHN的发病趋势。我们通过加权最小二乘法和连接点回归分析确定年度百分比变化（APC）。结果。1987年至2009年MMHN发病率上升（APC 2.4%；P < 0.01）。在此期间，鼻腔病变发病率上升（APC 2.7%；P < 0.01），而非鼻腔病变发病率保持稳定。发病率上升最高的是55至84岁的白人女性（APC 5.1%；P = 0.01）。结论。自1987年以来，美国MMHN的发病率一直在上升。这一趋势主要由鼻腔黑色素瘤发病率增加所驱动。
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