非对映选择性分子内氨甲酰基烯酮/烯烃 [2 + 2] 环加成：吡咯烷并吲哚生物碱的对映选择性方法。

Diastereoselective intramolecular carbamoylketene/alkene [2 + 2] cycloaddition: enantioselective access to pyrrolidinoindoline alkaloids.

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.

出版信息

Org Lett. 2013 Jan 4;15(1):200-3. doi: 10.1021/ol303204v. Epub 2012 Dec 19.

Abstract

A novel and highly diastereoselective intramolecular carbamoylketene/alkene [2 + 2] cycloaddition has been developed, and the methodology was successfully applied to the enantioselective syntheses of (-)-esermethole and Takayama's intermediate for (+)-psychotrimine.

摘要

发展了一种新型的、高非对映选择性的分子内氨甲酰基烯酮/烯烃 [2 + 2] 环加成反应，该方法成功应用于 (-)-esermethole 和 (+)-psychotrimine 的 Takayama 中间体的对映选择性合成。