多诺米 Domino 铑催化的邻氨基肉桂基衍生物的氢甲酰化-双环化反应：在手性金鸡纳生物碱 physostigmine 和 physovenine 的全合成中的应用。
Domino Rh-catalyzed hydroformylation-double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine.
机构信息
Department of Chemistry, National Chung Hsing University, Taichung, 402, Taiwan, ROC.
出版信息
Chem Commun (Camb). 2013 Sep 25;49(74):8232-4. doi: 10.1039/c3cc43257b.
PMID:23926596
Abstract
A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring a domino Rh-catalyzed hydroformylation-double cyclization sequence. This method can be applied to the syntheses of anti-Alzheimer drugs such as physostigmine and physovenine.
摘要
已经开发出了一种从肉桂基衍生物合成吡咯烷并吲哚啉和四氢呋喃并吲哚啉生物碱的平行、多功能且高效的路线，其特征在于包含了一个 Rh 催化的串联加氢甲酰化-双环化反应序列。该方法可以应用于合成抗阿尔茨海默病药物，如石杉碱甲和石杉碱乙。
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