Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, complesso universitario di Monserrato, S.S. 554, bivio per Sestu, Monserrato 09042, CA, Italy.
Molecules. 2013 Dec 13;18(12):15541-72. doi: 10.3390/molecules181215541.
In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000-2013.
在过去的十年中，已经发表了一些新的环丁烷和环丁酮的合成和功能化的方法。有机和生物催化的环保方法已经被开发出来，用于合成含有环丁烷的分子，并取得了有趣的结果。此外，最近还报道了一些生物活性化合物和药物的成功全合成，其中四元环是关键的中间体。因此，人们对这个领域的兴趣日益浓厚，这为科学界提供了一个很好的讨论点，揭示了具有合成潜力的刚性四元环碳环化合物。在这里，我们对 2000 年至 2013 年期间发表的关于环丁烷衍生物的对映选择性合成和功能化的文献进行了批判性的综述，特别关注无金属、低影响的方法。
