Luijendijk Paul, Bouma Berto J, Groenink Maarten, Boekholdt Matthijs, Hazekamp Mark G, Blom Nico A, Koolbergen Dave R, de Winter Robbert J, Mulder Barbara J M
Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
Expert Rev Cardiovasc Ther. 2012 Dec;10(12):1517-31. doi: 10.1586/erc.12.158.
Aortic coarctation is a common congenital cardiovascular defect, which can be diagnosed over a wide range of ages and with varying degrees of severity. Surgery has proven to be an effective treatment for the management of native aortic coarctation, and remains the treatment of choice in neonates. Balloon angioplasty with or without stenting has evolved rapidly over the past decade. Balloon angioplasty is the treatment of choice in children with re-coarctation, and currently available immediate results in native coarctation are similar with regards to gradient reduction as compared with surgery. However, both treatment options carry the risk of restenosis and aortic wall complications, especially after balloon angioplasty without stenting in native coarctation. On the other hand, stent implantation has shown excellent short-term results in both children beyond infancy and in adults with native coarctation. In patients with recurrent coarctation who are at high surgical risk, balloon angioplasty and stent repair offer a less invasive and equally effective method. Stent repair is preferred over balloon angioplasty in adults and outgrown children with a recurrent coarctation, as the risk for re-coarctation and aneurysm formation seems to be lower. Data with regard to long-term outcome after percutaneous treatment strategies are scarce. This review summarizes the current insights in the efficacy and safety of both surgical and transcatheter treatment options for aortic coarctation.
主动脉缩窄是一种常见的先天性心血管缺陷,可在广泛的年龄段被诊断出来,且严重程度各不相同。手术已被证明是治疗原发性主动脉缩窄的有效方法,并且仍然是新生儿的首选治疗方法。在过去十年中,有或没有支架置入的球囊血管成形术发展迅速。球囊血管成形术是治疗再缩窄儿童的首选方法,目前原发性缩窄的即时治疗效果在梯度降低方面与手术相似。然而,这两种治疗方法都有再狭窄和主动脉壁并发症的风险,尤其是在原发性缩窄的无支架球囊血管成形术后。另一方面,支架植入在婴儿期后的儿童和原发性缩窄的成人中都显示出优异的短期效果。对于手术风险高的复发性缩窄患者,球囊血管成形术和支架修复提供了一种侵入性较小且同样有效的方法。对于成人和已长大的复发性缩窄儿童,支架修复优于球囊血管成形术,因为再缩窄和动脉瘤形成的风险似乎更低。关于经皮治疗策略后的长期结果的数据很少。本综述总结了目前对主动脉缩窄手术和经导管治疗方案的疗效和安全性的见解。