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经皮球囊血管成形术治疗儿童主动脉缩窄的疗效和安全性。单中心经验的急性和中期结果。

The efficacy and safety of percutaneous balloon angioplasty for aortic coarctation in children. Acute and mid-term results in a single center experience.

机构信息

Department of Pediatrics, Faculty of Medicine, Taibah University, Madinah, Kingdom of Saudi Arabia. E-mail.

出版信息

Saudi Med J. 2020 Nov;41(11):1252-1258. doi: 10.15537/smj.2020.11.25452.

DOI:10.15537/smj.2020.11.25452
PMID:33130847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7804232/
Abstract

OBJECTIVES

To assess the efficacy and safety of balloon angioplasty (BAP) procedure for treatment of coarctation of the aorta (CoA) in children. Methods: A retrospective study included 27 consecutive children, underwent BAP for either native-CoA (Na-CoA) or recoarctation (Re-CoA). Medical records, echocardiographic findings, angiographic and hemodynamic data were collected from the hospital database. Follow‑up was scheduled at 1, 3, 6, 12 months after the procedure. The study took place over a period of 4.5 years, from April 2014 to January 2019, in Madinah Cardiac Center, Madinah, Northwest region, Saudi Arabia.

RESULTS

The mean age of patients was 11.86±8.96 months. Seven children had Na-CoA and 20 children had Re-CoA. The success rate of the procedure was achieved in 23 children (85%), as BAP reduced the mean systolic pressure gradient across the CoA (Na-CoA: from 45.28± 18.3 to 9.8± 6.57 mm Hg, p=0.0009), and in Re-CoA groups (from 42.48±16.7 to 10.9±8.5 mm Hg, p less than 0.0001). In mid-term follow-up, the need for re-intervention occurred in 8 children of the cohort (3 children [42.8%] from the Na-CoA group, and 5 children [25%] from the Re-CoA group).  Conclusions: Balloon angioplasty is considered a safe procedure for the management of CoA, but its efficacy remains questionable especially for young infants with Na-CoA type. However, it is a reliable option for managing Re-CoA children, with a lower rate of future re-intervention.

摘要

目的

评估球囊血管成形术(BAP)治疗儿童主动脉缩窄(CoA)的疗效和安全性。

方法

回顾性研究纳入 27 例连续接受 BAP 治疗的儿童,其中包括原发性 CoA(Na-CoA)和再狭窄(Re-CoA)。从医院数据库中收集病历、超声心动图检查结果、血管造影和血流动力学数据。术后 1、3、6、12 个月进行随访。本研究于 2014 年 4 月至 2019 年 1 月在沙特阿拉伯西北部城市麦地那的麦地那心脏中心进行,历时 4.5 年。

结果

患者平均年龄为 11.86±8.96 个月。7 例为 Na-CoA,20 例为 Re-CoA。23 例(85%)患儿手术成功,BAP 降低了 CoA 跨壁收缩压梯度,Na-CoA 组从(45.28±18.3)mmHg 降至(9.8±6.57)mmHg(p=0.0009),Re-CoA 组从(42.48±16.7)mmHg 降至(10.9±8.5)mmHg(p<0.0001)。中期随访中,8 例患儿(Na-CoA 组 3 例[42.8%],Re-CoA 组 5 例[25%])需要再次介入治疗。

结论

球囊血管成形术是治疗 CoA 的一种安全方法,但疗效仍存在争议,尤其是对原发性 CoA 类型的婴幼儿。然而,对于再狭窄的儿童,它是一种可靠的治疗选择,未来再次介入的风险较低。

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