Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Expert Rev Neurother. 2013 Jan;13(1):23-36. doi: 10.1586/ern.12.147.
Experiencing auditory verbal hallucinations is a prominent symptom in schizophrenia that also occurs in subjects at enhanced risk for psychosis and in the general population. Drug treatment of auditory hallucinations is challenging, because the current understanding is limited with respect to the neural mechanisms involved, as well as how CNS drugs, such as antipsychotics, influence the subjective experience and neurophysiology of hallucinations. In this article, the authors review studies of the effect of antipsychotic medication on brain activation as measured with functional MRI in patients with auditory verbal hallucinations. First, the authors examine the neural correlates of ongoing auditory hallucinations. Then, the authors critically discuss studies addressing the antipsychotic effect on the neural correlates of complex cognitive tasks. Current evidence suggests that blood oxygen level-dependant effects of antipsychotic drugs reflect specific, regional effects but studies on the neuropharmacology of auditory hallucinations are scarce. Future directions for pharmacological neuroimaging of auditory hallucinations are discussed.
体验听觉言语幻觉是精神分裂症的一个突出症状，也发生在精神病高危人群和普通人群中。听觉幻觉的药物治疗具有挑战性，因为目前对于涉及的神经机制以及中枢神经系统药物（如抗精神病药）如何影响幻觉的主观体验和神经生理学的理解有限。在本文中，作者综述了抗精神病药物对听觉言语幻觉患者功能磁共振成像测量的大脑激活的影响研究。首先，作者检查了持续听觉幻觉的神经相关性。然后，作者批判性地讨论了研究抗精神病药物对复杂认知任务的神经相关性的影响。目前的证据表明，抗精神病药物的血氧水平依赖性效应反映了特定的、区域性的效应，但听觉幻觉的神经药理学研究还很缺乏。讨论了听觉幻觉的药物神经影像学的未来研究方向。
