Department of Gastroenterology, Changi General Hospital, Singapore.
J Dig Dis. 2013 Feb;14(2):100-4. doi: 10.1111/1751-2980.12024.
This study was aimed to assess whether the efficacy of one-week triple therapy comprising of proton pump inhibitor, amoxicillin and clarithromycin (PPI/A/C) on Helicobacter pylori (H. pylori) infection in Singapore has decreased over the duration from 2005 to 2010.
The clinical data of H. pylori-positive patients treated with one-week PPI/A/C in 2005 and 2010 were reviewed retrospectively using a registry database. The primary endpoint was the difference in treatment success rate.
A total of 465 patients (n = 174 in 2005 and n = 291 in 2010) were analyzed. In 2010, compared with 2005, the mean age of patients was younger (47 vs 56 years, P < 0.001) and the proportion of foreigners was higher (19.9% vs 5.7%, P < 0.001). The success rate of H. pylori eradication remained similar over the two time periods (90.2% in 2005 vs 88.7% in 2010, P = 0.597). Multinomial logistic regression revealed that mean age, gender, diagnosis and nationality had no impact on the success of H. pylori eradication.
From 2005 to 2010, there was no significant decrease in the efficacy of one-week PPI/A/C for the treatment of H. pylori infection. This treatment regime remained an effective first-line therapy for H. pylori infection in Singapore.
本研究旨在评估质子泵抑制剂、阿莫西林和克拉霉素（PPI/A/C）一周三联疗法治疗新加坡幽门螺杆菌（H. pylori）感染的疗效是否在 2005 年至 2010 年期间有所下降。
回顾性使用登记数据库分析 2005 年和 2010 年接受一周 PPI/A/C 治疗的 H. pylori 阳性患者的临床数据。主要终点是治疗成功率的差异。
共分析了 465 例患者（2005 年 n = 174，2010 年 n = 291）。与 2005 年相比，2010 年患者的平均年龄更年轻（47 岁比 56 岁，P < 0.001），外国人比例更高（19.9%比 5.7%，P < 0.001）。两个时期 H. pylori 根除的成功率相似（2005 年为 90.2%，2010 年为 88.7%，P = 0.597）。多项逻辑回归显示，平均年龄、性别、诊断和国籍对 H. pylori 根除的成功率没有影响。
从 2005 年到 2010 年，PPI/A/C 一周三联疗法治疗 H. pylori 感染的疗效没有显著下降。这种治疗方案仍然是新加坡 H. pylori 感染的有效一线治疗方法。
