Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development.
作者信息
Mali Raghuveer Singh, Kapur Reuben
出版信息
Cell Cycle. 2013 Jan 1;12(1):7-8. doi: 10.4161/cc.23070. Epub 2012 Dec 19.
Abstract
摘要
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Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development.IA类磷脂酰肌醇-3激酶调节亚基在肥大细胞发育中的独特和冗余作用。
Cell Cycle. 2013 Jan 1;12(1):7-8. doi: 10.4161/cc.23070. Epub 2012 Dec 19.
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Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.I 类（A）PI3K 调节亚基 p85α 通过调节与生长和存活相关的基因介导肥大细胞发育。
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本文引用的文献
1
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.IA 类 PI3 激酶的 p85β 调节亚基负调节肥大细胞的生长、成熟和白血病发生。
Blood. 2012 Apr 26;119(17):3951-61. doi: 10.1182/blood-2011-05-355602. Epub 2012 Feb 29.
2
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.PI3K 通路通过小眼畸形转录因子驱动肥大细胞的成熟。
Blood. 2011 Sep 29;118(13):3459-69. doi: 10.1182/blood-2011-04-351809. Epub 2011 Jul 25.
3
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.磷酸肌醇3激酶的p85α调节亚基增强c-Jun氨基末端激酶介导的胰岛素抵抗。
Mol Cell Biol. 2007 Apr;27(8):2830-40. doi: 10.1128/MCB.00079-07. Epub 2007 Feb 5.
4
Mast cells in the development of adaptive immune responses.肥大细胞在适应性免疫反应的发展过程中。
Nat Immunol. 2005 Feb;6(2):135-42. doi: 10.1038/ni1158.
5
Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase.缺乏磷脂酰肌醇3激酶p85β亚基的小鼠中T细胞增殖增强。
J Immunol. 2004 Jun 1;172(11):6615-25. doi: 10.4049/jimmunol.172.11.6615.
6
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice.PI3K基因缺陷小鼠胃肠道肥大细胞的选择性缺失及免疫功能受损
Nat Immunol. 2002 Mar;3(3):295-304. doi: 10.1038/ni768. Epub 2002 Feb 19.
7
Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain.使用MITF缺乏拉链结构域的mi(ce)/mi(ce)突变小鼠证明了mi转录因子（MITF）的亮氨酸拉链结构域对肥大细胞分化的重要性。
Blood. 2001 Apr 1;97(7):2038-44. doi: 10.1182/blood.v97.7.2038.
8
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.在缺乏磷酸肌醇3激酶p85α的情况下，B细胞发育和增殖受损。
Science. 1999 Jan 15;283(5400):393-7. doi: 10.1126/science.283.5400.393.
9
Phosphoinositide kinases.磷酸肌醇激酶
Annu Rev Biochem. 1998;67:481-507. doi: 10.1146/annurev.biochem.67.1.481.
10
Mast cells.肥大细胞
Physiol Rev. 1997 Oct;77(4):1033-79. doi: 10.1152/physrev.1997.77.4.1033.
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