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Catalytic asymmetric Michael addition/cyclization of isothiocyanato oxindoles: highly efficient and versatile approach for the synthesis of 3,2'-pyrrolidinyl mono- and bi-spirooxindole frameworks.

作者信息

Cao Yi-Ming, Shen Fang-Fang, Zhang Fu-Ting, Wang Rui

机构信息

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, PR China.

出版信息

Chemistry. 2013 Jan 21;19(4):1184-8. doi: 10.1002/chem.201204114. Epub 2012 Dec 18.

DOI:10.1002/chem.201204114
PMID:23255227
Abstract
摘要

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Enantioselective cascade Michael addition/cyclization reactions of 3-nitro-2H-chromenes with 3-isothiocyanato oxindoles: efficient synthesis of functionalized polycyclic spirooxindoles.3-硝基-2H-色烯与3-异硫氰酸酯氧化吲哚的对映选择性串联迈克尔加成/环化反应：官能化多环螺氧化吲哚的高效合成
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3-isothiocyanato oxindoles serving as powerful and versatile precursors to structurally diverse dispirocyclic thiopyrrolidineoxindoles through a cascade Michael/cyclization process with amino-thiocarbamate catalysts.3-异硫氰酸基吲哚酮作为强大且多功能的前体，通过与氨基硫代氨基甲酸酯催化剂的级联迈克尔/环化反应，生成结构多样的双螺环硫代吡咯烷并吲哚酮。
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